Alcohol use disorders consist of disorders characterised by compulsive heavy alcohol use
and loss of control over alcohol intake. Alcohol use disorders are some of the most prevalent …

Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Interoceptive pathways may be manipulated at various levels to develop interventions to
improve symptoms in a range of disorders. Primarily through the lens of the respiratory …

The hunger hormone ghrelin activates the ghrelin receptor GHSR to stimulate food intake
and growth hormone secretion and regulate reward signaling. Acylation of ghrelin at Ser3 is …

Ghrelin is a peptide that is produced by endocrine cells that are primarily localized in the
stomach. Ghrelin receptors (GHSR) are expressed in the brain and periphery. Preclinical …

Substance use continues to contribute to significant morbidity and mortality in the United
States, for both women and men, more so than any other preventable health condition. To …

Discovered as a peptide involved in releasing growth hormone, ghrelin was initially
characterized as the “hunger hormone.” However, emerging research indicates that ghrelin …

Alcohol use disorder (AUD) is a leading cause of morbidity and mortality worldwide.
However, treatment options, including pharmacotherapies, are limited in number and …

The stress response is an adaptive means of maintaining physiological homeostasis in the
face of changing environmental conditions. However, protracted recruitment of stress …

Compounds known to be successful in the treatment of alcohol use disorder include the
aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and …