Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …

Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts and is
involved in a variety of tumor-promoting activities such as matrix remodeling, angiogenesis …

There is much cellular heterogeneity in the tumor microenvironment. The tumor epithelia
and stromal cells co-evolve, and this reciprocal relationship dictates almost every step of …

Cancer-associated fibroblasts (CAFs) were originally presumed to represent a
homogeneous population uniformly driving tumorigenesis, united by their morphology and …

The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

Chemotherapy resistance observed in patients with colorectal cancer (CRC) may be related
to the presence of cancer stem cells (CSCs), but the underlying mechanism (s) remain …

Tumors form a complex environment consisting of a variety of non-malignant cells.
Especially cancer-associated fibroblasts have been shown to have an important role for …

Fibroblast activation protein (FAP) is best known for its heightened expression in tumour
stroma. This atypical serine protease has both dipeptidyl peptidase and endopeptidase …

Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis
(CRCLM) resistance to antiangiogenic therapy. The current mechanisms underlying vessel …