The cyclin-dependent kinase 5 (CDK5) is known as an exceptional component of the CDK
family, due to its characteristic regulatory pathways and its atypical roles in comparison to …

Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic
workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by …

Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. Most of
our understanding of their functions has been obtained from studies in single-cell organisms …

Background It may be possible to discover new diagnostic or therapeutic peptides or
proteins from blood plasma by using liquid chromatography and tandem mass spectrometry …

The accumulation of β‑amyloid peptides (Aβ) in the brain is a hallmark of Alzheimer's
disease (AD). Studies have indicated that ginsenoside Rg1, a primary component of …

Simple Summary CMGC kinases, named after the initials of its main kinase families, C DKs,
M APKs, G SKs, and C LKs, play critical roles in many cellular processes. Dysregulation of …

Objective We aimed to investigate the roles and underlying mechanisms of YAP in the
proliferation of neuroblastoma cells. Methods The expression level of YAP was evaluated by …

High-resolution structural studies of proteins and protein complexes in a native eukaryotic
environment present a challenge to structural biology. In-cell NMR can characterize atomic …

Selective abrogation of cyclin-dependent kinases (CDK) activity is a highly promising
strategy in cancer treatment. The atypical CDK, CDK5 has long been known for its role in …

Proteins of the cyclin family have divergent sequences and execute diverse roles within the
cell while sharing a common fold: the cyclin box domain. Structural studies of cyclins have …