Cells recognize and respond to their extracellular environment through transmembrane
receptors such as integrins, which physically connect the extracellular matrix to the …

Cardiac fibrosis is one of the major components of the healing mechanism following any
injury of the heart and as such may contribute to both systolic and diastolic dysfunction in a …

Rationale: Systemic inflammation compromises the reparative properties of endothelial
progenitor cell (EPC) and their exosomes on myocardial repair, although the underlying …

Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions
and regulates many cellular processes, including growth, proliferation, survival …

During the last 15 years, the perception of the cardiac z-disc has undergone substantial
changes. Initially viewed as a structural component at the lateral boundaries of the …

Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions,
cell adhesion, and anchorage-dependent cell growth. It combines functions of a signal …

Obesity and insulin resistance are rapidly expanding public health problems. These
disturbances are related to many diseases, including heart pathology. Acting through the …

Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder
characterized by excessive heart rate increase on standing, leading to debilitating symptoms …

Background—As DNA sequencing costs decline, genetic testing options have expanded.
Whole exome sequencing and whole genome sequencing (WGS) are entering clinical use …

Cardiac hypertrophy entails complex structural remodeling involving rearrangement of
muscle fibers, interstitial fibrosis, accumulation of extracellular matrix, and angiogenesis …