Stem cell imaging: from bench to bedside
Although cellular therapies hold great promise for the treatment of human disease, results
from several initial clinical trials have not shown a level of efficacy required for their use as a …
from several initial clinical trials have not shown a level of efficacy required for their use as a …
Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair
ME Hartman, DF Dai, MA Laflamme - Advanced drug delivery reviews, 2016 - Elsevier
Human pluripotent stem cells (PSCs) represent an attractive source of cardiomyocytes with
potential applications including disease modeling, drug discovery and safety screening, and …
potential applications including disease modeling, drug discovery and safety screening, and …
Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model
Rationale: Tissue engineering approaches may improve survival and functional benefits
from human embryonic stem cell–derived cardiomyocyte transplantation, thereby potentially …
from human embryonic stem cell–derived cardiomyocyte transplantation, thereby potentially …
Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction
Q Wang, H Yang, A Bai, W Jiang, X Li, X Wang, Y Mao… - Biomaterials, 2016 - Elsevier
With the advent of induced pluripotent stem cells and directed differentiation techniques, it is
now feasible to derive individual-specific cardiac cells for human heart tissue engineering …
now feasible to derive individual-specific cardiac cells for human heart tissue engineering …
Potential strategies to address the major clinical barriers facing stem cell regenerative therapy for cardiovascular disease: a review
Importance Although progress continues to be made in the field of stem cell regenerative
medicine for the treatment of cardiovascular disease, significant barriers to clinical …
medicine for the treatment of cardiovascular disease, significant barriers to clinical …
Microfluidic single-cell analysis of transplanted human induced pluripotent stem cell–derived cardiomyocytes after acute myocardial infarction
Background—Human induced pluripotent stem cells (iPSCs) are attractive candidates for
therapeutic use, with the potential to replace deficient cells and to improve functional …
therapeutic use, with the potential to replace deficient cells and to improve functional …
[HTML][HTML] Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm
GL Szot, M Yadav, J Lang, E Kroon, J Kerr, K Kadoya… - Cell stem cell, 2015 - cell.com
Summary Type 1 diabetes (T1D) is an autoimmune disease caused by T cell-mediated
destruction of insulin-producing β cells in the islets of Langerhans. In most cases, reversal of …
destruction of insulin-producing β cells in the islets of Langerhans. In most cases, reversal of …
Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells
PA Schweizer, FF Darche, ND Ullrich… - Stem cell research & …, 2017 - Springer
Background Human induced pluripotent stem cells (hiPSC) harbor the potential to
differentiate into diverse cardiac cell types. Previous experimental efforts were primarily …
differentiate into diverse cardiac cell types. Previous experimental efforts were primarily …
Stem cell therapy for congenital heart disease: a systematic review
Background: Congenital heart disease (CHD) constitutes the most prevalent and
heterogeneous group of congenital anomalies. Although surgery remains the gold standard …
heterogeneous group of congenital anomalies. Although surgery remains the gold standard …
Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics
There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem
cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of …
cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of …