Proteomics beyond trypsin
L Tsiatsiani, AJR Heck - The FEBS journal, 2015 - Wiley Online Library
Peptide‐centered shotgun analysis of proteins has been the core technology in mass
spectrometry based proteomics and has enabled numerous biological discoveries, such as …
spectrometry based proteomics and has enabled numerous biological discoveries, such as …
Bakta: rapid and standardized annotation of bacterial genomes via alignment-free sequence identification
O Schwengers, L Jelonek… - Microbial …, 2021 - microbiologyresearch.org
Command-line annotation software tools have continuously gained popularity compared to
centralized online services due to the worldwide increase of sequenced bacterial genomes …
centralized online services due to the worldwide increase of sequenced bacterial genomes …
[HTML][HTML] Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma
The composition of the gut microbiome has been associated with clinical responses to
immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific …
immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific …
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles
SA Dilliard, Q Cheng… - Proceedings of the …, 2021 - National Acad Sciences
Lipid nanoparticles (LNPs) are a clinically mature technology for the delivery of genetic
medicines but have limited therapeutic applications due to liver accumulation. Recently, our …
medicines but have limited therapeutic applications due to liver accumulation. Recently, our …
Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users
Abstract The SIB Swiss Institute of Bioinformatics (https://www. sib. swiss) creates, maintains
and disseminates a portfolio of reliable and state-of-the-art bioinformatics services and …
and disseminates a portfolio of reliable and state-of-the-art bioinformatics services and …
The PSIPRED protein analysis workbench: 20 years on
DWA Buchan, DT Jones - Nucleic acids research, 2019 - academic.oup.com
The PSIPRED Workbench is a web server offering a range of predictive methods to the
bioscience community for 20 years. Here, we present the work we have completed to update …
bioscience community for 20 years. Here, we present the work we have completed to update …
[HTML][HTML] The cellosaurus, a cell-line knowledge resource
A Bairoch - Journal of biomolecular techniques: JBT, 2018 - ncbi.nlm.nih.gov
The Cellosaurus is a knowledge resource on cell lines. It aims to describe all cell lines used
in biomedical research. Its scope encompasses both vertebrates and invertebrates …
in biomedical research. Its scope encompasses both vertebrates and invertebrates …
[PDF][PDF] Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein
Liquid-liquid phase separation, driven by collective interactions among multivalent and
intrinsically disordered proteins, is thought to mediate the formation of membrane-less …
intrinsically disordered proteins, is thought to mediate the formation of membrane-less …
Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
Matrix stiffness potently regulates cellular behaviour in various biological contexts. In breast
tumours, the presence of dense clusters of collagen fibrils indicates increased matrix …
tumours, the presence of dense clusters of collagen fibrils indicates increased matrix …
[HTML][HTML] Unblending of transcriptional condensates in human repeat expansion disease
S Basu, SD Mackowiak, H Niskanen, D Knezevic… - Cell, 2020 - Elsevier
Expansions of amino acid repeats occur in> 20 inherited human disorders, and many occur
in intrinsically disordered regions (IDRs) of transcription factors (TFs). Such diseases are …
in intrinsically disordered regions (IDRs) of transcription factors (TFs). Such diseases are …