Hyaluronan-based hydrogel integrating exosomes for traumatic brain injury repair by promoting angiogenesis and neurogenesis

X Liu, C Wu, Y Zhang, S Chen, J Ding, Z Chen… - Carbohydrate …, 2023 - Elsevier
With wide clinical demands, therapies for traumatic brain injury (TBI) are far from satisfactory.
Combining the merits of stem cells but avoiding the risk of immunologic rejection, bone …

[HTML][HTML] 3D bioprinted multilayered cerebrovascular conduits to study cancer extravasation mechanism related with vascular geometry

W Park, JS Lee, G Gao, BS Kim, DW Cho - Nature Communications, 2023 - nature.com
Cerebral vessels are composed of highly complex structures that facilitate blood perfusion
necessary for meeting the high energy demands of the brain. Their geometrical complexities …

[HTML][HTML] Three-dimensional bioprinting of artificial blood vessel: Process, bioinks, and challenges

YC Hou, X Cui, Z Qin, C Su, G Zhang… - … Journal of Bioprinting, 2023 - ncbi.nlm.nih.gov
The coronary artery bypass grafting is a main treatment for restoring the blood supply to the
ischemic site by bypassing the narrow part, thereby improving the heart function of the …

Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

JA Ortega, GP Soares de Aguiar… - Wiley …, 2024 - Wiley Online Library
The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson's disease

J Xu, TY Chen, CH Tai, S Hsu - Biomaterials Research, 2023 - spj.science.org
Background Parkinson's disease (PD) is one of the most common long-term
neurodegenerative diseases. Current treatments for PD are mostly based on surgery and …

[HTML][HTML] Hypoxia-pretreated mesenchymal stem cell-derived exosomes-loaded low-temperature extrusion 3D-printed implants for neural regeneration after traumatic …

X Liu, J Wang, P Wang, L Zhong, S Wang… - … in bioengineering and …, 2022 - frontiersin.org
Regenerating brain defects after traumatic brain injury (TBI) still remains a significant
difficulty, which has motivated interest in 3D printing to design superior replacements for …

A generic pump‐free organ‐on‐a‐chip platform for assessment of intestinal drug absorption

Y Guo, Y Xie, J Qin - Biotechnology Journal, 2024 - Wiley Online Library
Organ‐on‐a‐chip technology has shown great potential in disease modeling and drug
evaluation. However, traditional organ‐on‐a‐chip devices are mostly pump‐dependent with …

3D chitosan scaffolds support expansion of human neural stem cells in chemically defined condition

FC Chang, MM James, AM Qassab, Y Zhou, Y Ando… - Matter, 2023 - cell.com
The use of human neural stem cells (hNSCs) for clinical cell therapies is limited by the lack
of effective culture substrates to produce hNSCs. Animal-sourced substrates could result in …

Decellularized extracellular matrix and mesenchymal stem cells promote recovery in traumatic brain injury by synergistically enhancing neurogenesis and attenuating …

X Zhang, B Wang, H Hong, Y Wang, J Liu, C Liu… - Journal of Materials …, 2023 - Elsevier
Damaged neurons and harsh microenvironments contribute to the injury cascades following
traumatic brain injury (TBI). Mesenchymal stem cell (MSC) therapy is considered a viable …

Stem cells in central nervous system diseases: Promising therapeutic strategies

C Ying, J Zhang, H Zhang, S Gao, X Guo, J Lin… - Experimental …, 2023 - Elsevier
Central nervous system (CNS) diseases are a leading cause of death and disability. Due to
CNS neurons have no self-renewal and regenerative ability as they mature, their loss after …