Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Natural products, being richly endowed with curative powers, have become spotlight for
biomedical and pharmaceutical research to develop novel therapeutics during recent years …

The phosphorylation status of oncoproteins is regulated by both kinases and phosphatases.
Kinase inhibitors are rarely sufficient for successful cancer treatment, and phosphatases …

Acute myeloid leukaemia (AML) is a group of malignant diseases of the haematopoietic
system. AML occurs as the result of mutations in haematopoietic stem/progenitor cells, which …

Abstract Phosphatase of Regenerating Liver-3 (PRL3) was discovered in 1998 and was
subsequently found to be correlated with cancer progression and metastasis in 2001 …

Phosphatases of regenerating liver (PRLs) are markers of cancer and promote tumor
growth. They have been implicated in a variety of biochemical pathways but the …

Hypoxia within the tumor microenvironment, which leads to excessive ROS and genomic
instability, is one of the hallmarks of cancer, contributing to self-renewal capability …

Therapeutic and diagnostic progresses have significantly reduced the mortality rate among
cancer patients during the last decade. However, there is still a high rate of mortality among …

Protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) regulate the level
of tyrosine phosphorylation in proteins. PTKs are key enzymes that catalyze the transfer of …

Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and
metastasis. The mechanisms that drive PRL-3's oncogenic functions are not well …