Dual role of indoles derived from intestinal microbiota on human health

X Ye, H Li, K Anjum, X Zhong, S Miao, G Zheng… - Frontiers in …, 2022 - frontiersin.org
Endogenous indole and its derivatives (indoles), considered as promising N-substituted
heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and …

Bifidobacterium longum: protection against inflammatory bowel disease

S Yao, Z Zhao, W Wang, X Liu - Journal of immunology …, 2021 - Wiley Online Library
The prevalence of inflammatory bowel disease (IBD), which includes ulcerative colitis (UC)
and Crohn's disease (CD), increases gradually worldwide in the past decades. IBD is …

Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut

MF Laursen, M Sakanaka, N von Burg, U Mörbe… - Nature …, 2021 - nature.com
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life
immune development, and the gut microbiota can impact host physiology in various ways …

[HTML][HTML] Bifidobacteria-mediated immune system imprinting early in life

BM Henrick, L Rodriguez, T Lakshmikanth, C Pou… - Cell, 2021 - cell.com
Immune-microbe interactions early in life influence the risk of allergies, asthma, and other
inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by …

Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis

N Sugimura, Q Li, ESH Chu, HCH Lau, W Fong, W Liu… - Gut, 2022 - gut.bmj.com
Objective Using faecal shotgun metagenomic sequencing, we identified the depletion of
Lactobacillus gallinarum in patients with colorectal cancer (CRC). We aimed to determine …

Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells

AM Ehrlich, AR Pacheco, BM Henrick, D Taft, G Xu… - BMC microbiology, 2020 - Springer
Background Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium
that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize …

High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice

Y Lai, CW Liu, Y Yang, YC Hsiao, H Ru, K Lu - Nature communications, 2021 - nature.com
The mammalian gut harbors a complex and dynamic microbial ecosystem: the microbiota.
While emerging studies support that microbiota regulates brain function with a few molecular …

New insights into gut-bacteria-derived indole and its derivatives in intestinal and liver diseases

X Li, B Zhang, Y Hu, Y Zhao - Frontiers in Pharmacology, 2021 - frontiersin.org
The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …

Priority effects shape the structure of infant-type Bifidobacterium communities on human milk oligosaccharides

MN Ojima, L Jiang, AA Arzamasov, K Yoshida… - The ISME …, 2022 - academic.oup.com
Bifidobacteria are among the first colonizers of the infant gut, and human milk
oligosaccharides (HMOs) in breastmilk are instrumental for the formation of a bifidobacteria …

Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation

JR Liu, H Miao, DQ Deng, ND Vaziri, P Li… - Cellular and Molecular …, 2021 - Springer
The gut microbiota has a crucial effect on regulating the intestinal mucosal immunity and
maintaining intestinal homeostasis both in health and in disease state. Many effects are …