Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
CFA Ramirez, D Taranto, M Ando-Kuri… - Nature …, 2024 - nature.com
Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-
tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course …
tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course …
Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma
A Mulero‐Sánchez, CFA Ramirez… - Molecular …, 2023 - Wiley Online Library
Liver cancer is the fourth most common cause of cancer‐related death worldwide, with
hepatocellular carcinoma (HCC) being the main primary malignancy affecting the liver …
hepatocellular carcinoma (HCC) being the main primary malignancy affecting the liver …
Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma
A Lozano, FR Souche, C Chavey, V Dardalhon… - Elife, 2023 - elifesciences.org
Quantitative differences in signal transduction are to date an understudied feature of tumour
heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human …
heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human …
Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of primary and metastatic hepatocellular carcinoma
A Lozano, FR Souche, C Ramirez, S Vegna… - bioRxiv, 2021 - biorxiv.org
Quantitative differences in signal transduction are to date an understudied feature of tumour
heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human …
heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human …