Advancements and challenges in antifungal therapeutic development

E Puumala, S Fallah, N Robbins… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Over recent decades, the global burden of fungal disease has expanded dramatically. It is
estimated that fungal disease kills approximately 1.5 million individuals annually; however …

Immunocompromised host section: Adoptive T-cell therapy for dsDNA viruses in allogeneic hematopoietic cell transplant recipients

CS Walti, C Stuehler, D Palianina… - Current Opinion in …, 2022 - journals.lww.com
Immunocompromised host section: Adoptive T-cell therapy for... : Current Opinion in
Infectious Diseases Immunocompromised host section: Adoptive T-cell therapy for dsDNA …

Final outcomes from a phase 2 trial of posoleucel in allogeneic hematopoietic cell transplant recipients

SS Dadwal, R Bansal, MW Schuster, JA Yared… - Blood …, 2024 - ashpublications.org
Allogeneic hematopoietic cell transplantation (allo-HCT) recipients are susceptible to viral
infections. We conducted a phase 2 trial evaluating the safety and rate of clinically significant …

Adoptive immunotherapy for prophylaxis and treatment of cytomegalovirus infection

CP Ouellette - Viruses, 2022 - mdpi.com
Cytomegalovirus (CMV), a member of the Herpesviridae family, is frequent among
hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients in absence …

Epstein–Barr virus posttransplant lymphoproliferative disorder: update on management and outcomes

J Lindsay, J Othman, MR Heldman… - Current opinion in …, 2021 - journals.lww.com
With an increasing number of risk groups for developing EBV PTLD in HCT and SOT,
management strategies using prophylaxis or preemptive therapy remain standard of care …

T cell responses to control fungal infection in an immunological memory lens

J Sharma, S Mudalagiriyappa… - Frontiers in …, 2022 - frontiersin.org
In recent years, fungal vaccine research emanated significant findings in the field of
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …

Haploidentical stem cell transplantation for acute myeloid leukemia: current therapies, challenges and future prospective

YJ Chang, XY Zhao, XJ Huang - Frontiers in Oncology, 2021 - frontiersin.org
Haploidentical stem cell transplantation (haplo-SCT), an alternative donor source, offers a
curative therapy for patients with acute myeloid leukemia (AML) who are transplant …

Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant

JD Rubinstein, C Lutzko, T Leemhuis, X Zhu… - Blood …, 2022 - ashpublications.org
Infections with double-stranded DNA viruses are a significant cause of morbidity and
mortality in pediatric patients following allogeneic hematopoietic stem cell transplantation …

[HTML][HTML] Pathogen-specific T cells: targeting old enemies and new invaders in transplantation and beyond

A Papadopoulou, M Alvanou, G Karavalakis… - …, 2023 - journals.lww.com
Adoptive immunotherapy with virus-specific cytotoxic T cells (VSTs) has evolved over the
last three decades as a strategy to rapidly restore virus-specific immunity to prevent or treat …

Virus specific T cell therapy to treat refractory viral infections in solid organ transplant recipients

L Schweitzer, P Muranski - American Journal of Transplantation, 2024 - Elsevier
Solid organ transplant recipients require ongoing immunosuppression to prevent acute
rejection, which puts them at risk for opportunistic infections. Viral infections are particularly …