Comprehensive coverage on anti-mycobacterial endeavour reported during 2022
TM Dhameliya, DD Vekariya, HY Patel… - European Journal of …, 2023 - Elsevier
TB being one of the deadliest diseases and second most common infectious cause of
deaths, poses the severe threat to global health. The extended duration of therapy owing to …
deaths, poses the severe threat to global health. The extended duration of therapy owing to …
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease
SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health
and economy. Till producing successful vaccination strategies, the healthcare sectors …
and economy. Till producing successful vaccination strategies, the healthcare sectors …
Isatin Derivatives: A Frontier in Antimicrobial Agents
S Shaik, M Chaudhary, C Kaur… - Letters in Organic …, 2024 - ingentaconnect.com
Microbial infection is one of the major concerns for human health in the modern era.
Condition is further worsening due to the development of resistance by the microbe against …
Condition is further worsening due to the development of resistance by the microbe against …
[HTML][HTML] Design, synthesis and molecular modeling of isatin-aminobenzoic acid hybrids as antibacterial and antibiofilm agents
AA Radwan, FK Al-Anazi, M Al-Agamy… - Saudi Pharmaceutical …, 2023 - Elsevier
Abstract Number of factors, including newly emerging infectious diseases and an increase in
multi-drug resistant microbial pathogens with particular relevance for Gram-positive bacteria …
multi-drug resistant microbial pathogens with particular relevance for Gram-positive bacteria …
Identification of new anti-mycobacterial agents based on quinoline-isatin hybrids targeting enoyl acyl carrier protein reductase (InhA)
EF Khaleel, A Sabt, M Korycka-Machala, RM Badi… - Bioorganic …, 2024 - Elsevier
Tuberculosis (TB) is a global issue that poses a significant economic burden as a result of
the ongoing emergence of drug-resistant strains. The urgent requirement for the …
the ongoing emergence of drug-resistant strains. The urgent requirement for the …
Identification of 2-(N-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity
A Sabt, MH Abdulla, MS Ebaid, J Pawełczyk… - Frontiers in …, 2024 - frontiersin.org
The spread of drug-resistant tuberculosis strains has become a significant economic burden
globally. To tackle this challenge, there is a need to develop new drugs that target specific …
globally. To tackle this challenge, there is a need to develop new drugs that target specific …
Design and synthesis of benzo[b]thiophene‐based hybrids as novel antitubercular agents against MDR/XDR Mycobacterium tuberculosis
T Al‐Warhi, NM Rashad, H Almahli… - Archiv der …, 2024 - Wiley Online Library
In an effort to support the global fight against tuberculosis (TB), which is widely recognized
as the most lethal infectious disease worldwide, we present the design and synthesis of new …
as the most lethal infectious disease worldwide, we present the design and synthesis of new …
[HTML][HTML] Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches
In the development of novel antidiabetic agents, a novel series of isoxazolidine-isatin
hybrids were designed, synthesized, and evaluated as dual α‐amylase and α-glucosidase …
hybrids were designed, synthesized, and evaluated as dual α‐amylase and α-glucosidase …
Discovery of new quinoline derivatives bearing 1-aryl-1, 2, 3-triazole motif as influenza H1N1 virus neuraminidase inhibitors
A Sabt, EF Khaleel, MA Shaldam, MS Ebaid… - Bioorganic …, 2024 - Elsevier
Sporadically and periodically, influenza outbreaks threaten global health and the economy.
Antigen drift-induced influenza virus mutations hamper antiviral drug development. Thus, a …
Antigen drift-induced influenza virus mutations hamper antiviral drug development. Thus, a …