IgA-dominated humoral immune responses govern patients' outcome in endometrial cancer
Recent studies suggest that B cells could play an important role in the tumor
microenvironment. However, the role of humoral responses in endometrial cancer remains …
microenvironment. However, the role of humoral responses in endometrial cancer remains …
Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase
Y Chen, Y Li, J Gao, Q Yu, Y Zhang, J Zhang - European Journal of …, 2024 - Elsevier
As a cytosolic enzyme involved in the purine salvage pathway metabolism, purine
nucleoside phosphorylase (PNP) plays an important role in a variety of cellular functions but …
nucleoside phosphorylase (PNP) plays an important role in a variety of cellular functions but …
Computational, in vitro and radiation-based in vivo studies on acetamide quinazolinone derivatives as new proposed purine nucleoside phosphorylase inhibitors for …
The present work describes a quinazolinone-based lead optimization for the development of
novel purine nucleoside phosphorylase (PNP) inhibitors with quinazolinone scaffold …
novel purine nucleoside phosphorylase (PNP) inhibitors with quinazolinone scaffold …
Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons
Purine nucleoside phosphorylase (PNP) is an important enzyme in the purine degradation
and salvage pathway. PNP deficiency results in marked T lineage lymphopenia and severe …
and salvage pathway. PNP deficiency results in marked T lineage lymphopenia and severe …
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
J Skácel, S Djukic, O Baszczyňski… - Journal of Medicinal …, 2023 - ACS Publications
Purine nucleoside phosphorylase (PNP) is a well-known molecular target with potential
therapeutic applications in the treatment of T-cell malignancies and/or bacterial/parasitic …
therapeutic applications in the treatment of T-cell malignancies and/or bacterial/parasitic …
Exploring the potential mechanisms of Rehmannia glutinosa in treating sepsis based on network pharmacology
H Wang, Y Laram, L Hu, Y Hu, M Chen - BMC Infectious Diseases, 2024 - Springer
The present study utilized network pharmacology to identify therapeutic targets and
mechanisms of Rehmannia glutinosa in sepsis treatment. RNA-sequencing was conducted …
mechanisms of Rehmannia glutinosa in sepsis treatment. RNA-sequencing was conducted …
Unfolding new roles for guanine-based purines and their metabolizing enzymes in cancer and aging disorders
The ubiquitous purinergic system is composed by adenine-and guanine-based compounds,
their converting enzymes (Yegutkin, 2014), and by the adenosine (P1) G protein-coupled …
their converting enzymes (Yegutkin, 2014), and by the adenosine (P1) G protein-coupled …
Spermidine attenuates monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting purine metabolism and polyamine synthesis-associated vascular …
Y Chen, H Li, F Zhao, M Yu, S Pan, W Sun, Y Yin… - International …, 2024 - Elsevier
Ensuring the homeostatic integrity of pulmonary artery endothelial cells (PAECs) is essential
for combatting pulmonary arterial hypertension (PAH), as it equips the cells to withstand …
for combatting pulmonary arterial hypertension (PAH), as it equips the cells to withstand …
Sink or Swim: Mechanisms of dNTP Pool Elevation by Lentiviruses and Cancer
NE Bowen - 2023 - search.proquest.com
The sole utility of deoxynucleoside triphosphates (dNTPs) is to serve as substrates for DNA
polymerase during DNA synthesis. Correspondingly, dNTP concentrations elevate at the …
polymerase during DNA synthesis. Correspondingly, dNTP concentrations elevate at the …