Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors
The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
Ribosomal stalling during translation: providing substrates for ribosome-associated protein quality control
CAP Joazeiro - Annual review of cell and developmental biology, 2017 - annualreviews.org
Cells of all organisms survey problems during translation elongation, which may happen as
a consequence of mRNA aberrations, inefficient decoding, or other sources. In eukaryotes …
a consequence of mRNA aberrations, inefficient decoding, or other sources. In eukaryotes …
[HTML][HTML] Quantitative proteomics of the cancer cell line encyclopedia
Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …
Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways
K Ikeuchi, P Tesina, Y Matsuo, T Sugiyama… - The EMBO …, 2019 - embopress.org
Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay)
and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires …
and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires …
Structure of Gcn1 bound to stalled and colliding 80S ribosomes
AA Pochopien, B Beckert… - Proceedings of the …, 2021 - National Acad Sciences
The Gcn pathway is conserved in all eukaryotes, including mammals such as humans,
where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential …
where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential …
[HTML][HTML] Ribosome collisions trigger cis-acting feedback inhibition of translation initiation
Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with
trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate …
trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate …
[HTML][HTML] Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the
production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the …
production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the …
Molecular mechanism of translational stalling by inhibitory codon combinations and poly (A) tracts
Inhibitory codon pairs and poly (A) tracts within the translated mRNA cause ribosome
stalling and reduce protein output. The molecular mechanisms that drive these stalling …
stalling and reduce protein output. The molecular mechanisms that drive these stalling …
[HTML][HTML] Structural basis for clearing of ribosome collisions by the RQT complex
K Best, K Ikeuchi, L Kater, D Best, J Musial… - Nature …, 2023 - nature.com
Translation of aberrant messenger RNAs can cause stalling of ribosomes resulting in
ribosomal collisions. Collided ribosomes are specifically recognized to initiate stress …
ribosomal collisions. Collided ribosomes are specifically recognized to initiate stress …
Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
3′ RNA decay pathways are critical for quality control and regulation of gene expression.
Structural and biochemical studies have provided insights into the key nucleases that carry …
Structural and biochemical studies have provided insights into the key nucleases that carry …