The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …

Cells of all organisms survey problems during translation elongation, which may happen as
a consequence of mRNA aberrations, inefficient decoding, or other sources. In eukaryotes …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay)
and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires …

The Gcn pathway is conserved in all eukaryotes, including mammals such as humans,
where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an essential …

Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with
trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate …

Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the
production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the …

Inhibitory codon pairs and poly (A) tracts within the translated mRNA cause ribosome
stalling and reduce protein output. The molecular mechanisms that drive these stalling …

Translation of aberrant messenger RNAs can cause stalling of ribosomes resulting in
ribosomal collisions. Collided ribosomes are specifically recognized to initiate stress …

3′ RNA decay pathways are critical for quality control and regulation of gene expression.
Structural and biochemical studies have provided insights into the key nucleases that carry …