The transport of proteins across the nuclear membrane is a highly regulated process,
essential for the cell function. This transport is actively mediated by members of the …

Nucleophosmin (NPM1) is a mainly nucleolar protein that shuttles between nucleoli,
nucleoplasm and cytoplasm to fulfill its many functions. It is a chaperone of both nucleic …

Acute myeloid leukemia (AML) is a heterogeneous disease with variable patient responses
to therapy. Selinexor, an inhibitor of nuclear export, has shown promising clinical activity for …

Selinexor is a first-in-class inhibitor of the nuclear exportin XPO1 that was recently approved
by the US Food and Drug Administration for the treatment of multiple myeloma and diffuse …

PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical
plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo …

Hyponatremia is the most common electrolyte disorder in clinical practice and is associated
with increased morbidity and mortality. It is frequently encountered in hematologic patients …

Liposarcoma (LPS) is a common soft tissue sarcoma that encompasses diverse subtypes of
well-differentiated/dedifferentiated, myxoid/round cell, and pleomorphic LPS. There is …

Simple Summary The interactions between Acute Myeloid Leukaemia (AML) cells and the
surrounding bone marrow (BM) tissue contribute to blocking the efficacy of current drug …

Abstract Exportin 1 (XPO1), also known as chromosome maintenance 1 protein (CRM1), is
the main transporter for hundreds of proteins like tumor suppressors, growth regulatory …

Prognosis for relapsed or refractory (R/R) acute myeloid leukemia (AML) despite salvage
therapy is dismal. This phase I dose-escalation trial assessed the safety and preliminary …