Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …

Synthetic biology has established powerful tools to precisely control cell function.
Engineering these systems to meet clinical requirements has enormous medical …

High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast
cancer. Elucidating the cross-talk between Notch and other major breast cancer pathways is …

Notch signaling is controlled by ligand binding, which unfolds a negative control region to
induce proteolytic cleavage of the receptor. First, a membrane-proximal cleavage is …

The differentiation of stem cells into smooth muscle cells (SMCs) plays an important role in
vascular development and remodeling. In addition, stem cells represent a potential source of …

The amyloid precursor protein (APP) plays a central role in Alzheimer's disease, but its
physiological function and that of its mammalian paralogs, the amyloid precursor‐like …

Processing of the amyloid precursor protein (APP) by β‐and γ‐secretases leads to the
generation of amyloid‐β (Aβ) peptides with varying lengths. Particularly Aβ42 contributes to …

Proliferating investigations of the Notch pathway have given rise to the Notch “field,” which
has grown exponentially over the past 30 years. This field, founded by investigations of …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …