Highlights•IDRs exist as diverse and dynamic populations of interchanging structural
conformations.•Subsets of these conformations can have distinct functions.•Cell state …

Prevalent in nature, protein oligomers play critical roles both physiologically and
pathologically. The multimeric nature and conformational transiency of protein oligomers …

Self-assembling cyclic protein homo-oligomers play important roles in biology, and the
ability to generate custom homo-oligomeric structures could enable new approaches to …

Oligomerization has been suggested to be an important mechanism for increasing or
maintaining the thermostability of proteins. Although it is evident that protein–protein …

Background Narrow host range is a major limitation for phage applications, but phages can
evolve expanded host range through adaptations in the receptor-binding proteins. Results …

Highlights•Homomeric interfaces are a pool of potential allosteric sites for challenging
targets.•Homomeric disruption can lead to target degradation and sub-stoichiometric …

In order to counter the malarial parasite's striking ability to rapidly develop drug resistance, a
constant supply of novel antimalarial drugs and potential drug targets must be available. The …

Mechanistic insights into protein–ligand interactions can yield chemical tools for modulating
protein function and enable their use for therapeutic purposes. For the homodimeric enzyme …

Malaria remains a major threat to human health, as strains resistant to current therapeutics
are discovered. Efforts in finding new drug targets are hampered by the lack of sufficiently …

Human D-3-phosphoglycerate dehydrogenase (PHGDH), a key enzyme in de novo serine
biosynthesis, is amplified in various cancers and serves as a potential target for anticancer …