The functional meaning of 5′ UTR in protein-coding genes
N Ryczek, A Łyś, I Makałowska - International Journal of Molecular …, 2023 - mdpi.com
As it is well known, messenger RNA has many regulatory regions along its sequence length.
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …
Meiosis in budding yeast
GV Börner, A Hochwagen, AJ MacQueen - Genetics, 2023 - academic.oup.com
Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …
two meiotic divisions reduce chromosome number by half, typically generating haploid …
Pervasive, coordinated protein-level changes driven by transcript isoform switching during meiosis
To better understand the gene regulatory mechanisms that program developmental
processes, we carried out simultaneous genome-wide measurements of mRNA, translation …
processes, we carried out simultaneous genome-wide measurements of mRNA, translation …
Monitoring the 5′ UTR landscape reveals isoform switches to drive translational efficiencies in cancer
R Weber, U Ghoshdastider, D Spies, C Duré… - Oncogene, 2023 - nature.com
Transcriptional and translational control are key determinants of gene expression, however,
to what extent these two processes can be collectively coordinated is still poorly understood …
to what extent these two processes can be collectively coordinated is still poorly understood …
Causal role of a promoter polymorphism in natural variation of the Arabidopsis floral repressor gene FLC
Noncoding polymorphism frequently associates with phenotypic variation, but causation and
mechanism are rarely established. Noncoding single-nucleotide polymorphisms (SNPs) …
mechanism are rarely established. Noncoding single-nucleotide polymorphisms (SNPs) …
Cycloheximide can distort measurements of mRNA levels and translation efficiency
Regulation of the efficiency with which an mRNA is translated into proteins represents a key
mechanism for controlling gene expression. Such regulation impacts the number of actively …
mechanism for controlling gene expression. Such regulation impacts the number of actively …
The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles
I Ensinck, A Maman, WS Albihlal, M Lassandro… - Elife, 2023 - elifesciences.org
Abstract N6-methyladenosine (m6A), the most abundant mRNA modification, is deposited in
mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic …
mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic …
Kinetochore inactivation by expression of a repressive mRNA
Differentiation programs such as meiosis depend on extensive gene regulation to mediate
cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the …
cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the …
High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts
Background The start and end sites of messenger RNAs (TSSs and TESs) are highly
regulated, often in a cell-type-specific manner. Yet the contribution of transcript diversity in …
regulated, often in a cell-type-specific manner. Yet the contribution of transcript diversity in …
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast
RA Varier, T Sideri, C Capitanchik, Z Manova… - Elife, 2022 - elifesciences.org
Abstract N6-methyladenosine (m6A) RNA modification impacts mRNA fate primarily via
reader proteins, which dictate processes in development, stress, and disease. Yet little is …
reader proteins, which dictate processes in development, stress, and disease. Yet little is …