Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …

In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

The Integrator is a specialized 3′ end-processing complex involved in cleavage and
transcription termination of a subset of nascent RNA polymerase II transcripts, including …

The Integrator complex is a multi-subunit protein complex that regulates the processing of
nascent RNAs transcribed by RNA polymerase II (RNAPII), including small nuclear RNAs …

The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal
region of genes. Previous work has shed light on how Integrator binds to the paused …

Oral-facial-digital syndromes (OFDS) are a group of clinically and genetically
heterogeneous disorders characterized by defects in the development of the face and oral …

Mutations in BRAT1, encoding BRCA1-associated ATM activator 1, have been associated
with neurodevelopmental and neurodegenerative disorders characterized by …

In high-throughput functional genomic screens, each gene product is commonly assumed to
exhibit a singular biological function within a defined protein complex or pathway. In …

The metazoan-specific Integrator complex is a> 1.5 MDa machinery that interacts with RNA
polymerase II (RNAP2) to attenuate coding gene transcription by early termination close to …