Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …

Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Drug repositioning is a powerful method that can assists the conventional drug discovery
process by using existing drugs for treatment of a disease rather than its original indication …

Proton pump inhibitors (PPIs) are one of the most common medications taken by patients
worldwide. PPIs are used to treat acid‐related disorders, including gastroesophageal reflux …

In recent years, proton pump inhibitors (PPIs) have been criticized for their various adverse
interactions and side effects, creating a dilemma among practitioners regarding their use …

Drug repositioning, as a smart way to exploit new molecular targets of a known drug, has
been gaining increasing attention in the discovery of anti-cancer drugs. Proton pump …

Simple Summary Cancer is a major public health problem worldwide, and addressing its
morbidity, mortality, and prevalence is the first step towards appropriate control measures …

Abstract TOPK/PBK (T-LAK Cell-Originated Protein Kinase) is a serine/threonine kinase that
is highly expressed in a variety of human tumors and is associated with poor prognosis in …

One of the unsolved mysteries in oncology includes the strategies that cancer cells adopt to
cope with an adverse microenvironment. However, we knew, from the Warburg's discovery …

Objectives: Increasing evidence suggested that proton pump inhibitors (PPIs) use might
affect the development of cancers, but previous conclusions remain controversial. Therefore …