Ischemia and no obstructive coronary artery disease (INOCA) developing evidence-based therapies and research agenda for the next decade

CN Bairey Merz, CJ Pepine, MN Walsh, JL Fleg… - Circulation, 2017 - Am Heart Assoc
The Cardiovascular Disease in Women Committee of the American College of Cardiology,
in conjunction with interested parties (from the National Heart, Lung, and Blood Institute …

Reappraisal of ischemic heart disease: fundamental role of coronary microvascular dysfunction in the pathogenesis of angina pectoris

JC Kaski, F Crea, BJ Gersh, PG Camici - Circulation, 2018 - Am Heart Assoc
In recent years, it has become apparent that coronary microvascular dysfunction plays a
pivotal pathogenic role in angina pectoris. Functional and structural mechanisms can affect …

2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European …

Task Force Members, G Montalescot… - European heart …, 2013 - academic.oup.com
Surveys and registries are needed to verify that real-life daily practice is in keeping with what
is recommended in the guidelines, thus completing the loop between clinical research …

Coronary microvascular dysfunction: an update

F Crea, PG Camici, CN Bairey Merz - European heart journal, 2014 - academic.oup.com
Many patients undergoing coronary angiography because of chest pain syndromes,
believed to be indicative of obstructive atherosclerosis of the epicardial coronary arteries …

Treatment of coronary microvascular dysfunction

CN Bairey Merz, CJ Pepine… - Cardiovascular …, 2020 - academic.oup.com
Contemporary data indicate that patients with signs and symptoms of ischaemia and non-
obstructive coronary artery disease (INOCA) often have coronary microvascular dysfunction …

Sex differences in cardiovascular disease–impact on care and outcomes

KH Humphries, M Izadnegahdar, T Sedlak… - Frontiers in …, 2017 - Elsevier
Globally, cardiovascular disease (CVD) is the number one killer of women; one third of
female deaths are due to ischemic heart disease and stroke (WHO, 2013). Historically …

Emergence of nonobstructive coronary artery disease: a woman's problem and need for change in definition on angiography

CJ Pepine, KC Ferdinand, LJ Shaw… - Journal of the American …, 2015 - jacc.org
Recognition of ischemic heart disease (IHD) is often delayed or deferred in women. Thus,
many at risk for adverse outcomes are not provided specific diagnostic, preventive, and/or …

Women and ischemic heart disease: evolving knowledge

LJ Shaw, R Bugiardini, CNB Merz - Journal of the American College of …, 2009 - jacc.org
Evolving knowledge regarding sex differences in coronary heart disease is emerging. Given
the lower burden of obstructive coronary artery disease (CAD) and preserved systolic …

Primary coronary microvascular dysfunction: clinical presentation, pathophysiology, and management

GA Lanza, F Crea - Circulation, 2010 - Am Heart Assoc
Myocardial ischemia is usually caused by abnormalities of epicardial coronary arteries. In
the past 30 years, however, several studies have shown that abnormalities in coronary …

Ischemia and no obstructive coronary artery disease (INOCA): what is the risk?

R Herscovici, T Sedlak, J Wei, CJ Pepine… - Journal of the …, 2018 - Am Heart Assoc
An increasing number of stable patients with evidence of ischemia but no obstructive
coronary artery disease (CAD) at coronary angiography, now termed INOCA, are seen …