▪ Abstract L1 retrotransposons comprise 17% of the human genome. Although most L1s are
inactive, some elements remain capable of retrotransposition. L1 elements have a long …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

Toll-like receptors (TLRs) recognize microbial components, and evoke inflammation and
immune responses,,. TLR stimulation activates complex gene expression networks that …

Inhibition of the nuclear export of poly (A)-containing mRNAs caused by the influenza A virus
NS1 protein requires its effector domain. Here, we demonstrate that the NS1 effector domain …

A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and has
been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …

AAUAAA is the most highly conserved motif in eukaryotic mRNA polyadenylation sites and,
in mammals, is specifically recognized by the multisubunit CPSF (cleavage and …

Nearly all eukaryotic messenger RNA precursors must undergo cleavage and
polyadenylation at their 3′-end for maturation. A crucial step in this process is the …

Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …

Cleavage and polyadenylation specificity factor (CPSF) is the central component of the 3′
processing machinery for polyadenylated mRNAs in metazoans: CPSF recognizes the …

It is estimated that∼ 2500 genes are essential for the normal development of a zebrafish
embryo. A mutation in any one of these genes can result in a visible developmental defect …