Cerebral blood vessel damage in traumatic brain injury

KL Monson, MI Converse, GT Manley - Clinical biomechanics, 2019 - Elsevier
Traumatic brain injury is a devastating cause of death and disability. Although injury of brain
tissue is of primary interest in head trauma, nearly all significant cases include damage of …

Chemokine signaling mediated monocyte infiltration affects anxiety-like behavior following blast injury

M Murugan, A Ravula, A Gandhi, G Vegunta… - Brain, Behavior, and …, 2020 - Elsevier
The activation of resident microglia and infiltrated monocytes are known potent mediators of
chronic neuroinflammation following traumatic brain injury (TBI). In this study, we use a …

A 3-D rat brain model for blast-wave exposure: effects of brain vasculature and material properties

G Unnikrishnan, H Mao, A Sundaramurthy… - Annals of Biomedical …, 2019 - Springer
Exposure to blast waves is suspected to cause primary traumatic brain injury. However,
existing finite-element (FE) models of the rat head lack the necessary fidelity to characterize …

Cerebral vasculature influences blast-induced biomechanical responses of human brain tissue

DR Subramaniam, G Unnikrishnan… - … in bioengineering and …, 2021 - frontiersin.org
Multiple finite-element (FE) models to predict the biomechanical responses in the human
brain resulting from the interaction with blast waves have established the importance of …

A strain rate-dependent constitutive model for Göttingen Minipig cerebral arteries

N Pearson, GM Boiczyk, VB Kote… - Journal of …, 2022 - asmedigitalcollection.asme.org
Computational simulations of traumatic brain injury (TBI) are commonly used to advance
understanding of the injury–pathology relationship, tissue damage thresholds, and design of …

Quantitative electroencephalography in a swine model of blast-induced brain injury

C Chen, C Zhou, JM Cavanaugh, S Kallakuri, A Desai… - Brain Injury, 2017 - Taylor & Francis
Objective: Electroencephalography (EEG) was used to examine brain activity abnormalities
earlier after blast exposure using a swine model to develop a qEEG data analysis protocol …

A 3-D finite-element minipig model to assess brain biomechanical responses to blast exposure

A Sundaramurthy, VB Kote, N Pearson… - … in Bioengineering and …, 2021 - frontiersin.org
Despite years of research, it is still unknown whether the interaction of explosion-induced
blast waves with the head causes injury to the human brain. One way to fill this gap is to use …

The effect of three-dimensional whole, major, and small vasculature on mouse brain strain under both diffuse and focal brain injury loading

L Lu, X Liu, K Bian, JG Sled… - Journal of …, 2022 - asmedigitalcollection.asme.org
Blood vessels are much stiffer than brain parenchyma and their effects in finite element (FE)
brain models need to be investigated. Despite the publication of some comprehensive three …

Elucidating the role of compression waves and impact duration for generating mild traumatic brain injury in rats

BP Lucke-Wold, M Phillips, RC Turner, AF Logsdon… - Brain injury, 2017 - Taylor & Francis
Abstract Background: In total, 3.8 million concussions occur each year in the US leading to
acute functional deficits, but the underlying histopathologic changes that occur are relatively …

Characterization of closed head impact injury in rat

Y Hua, P Akula, M Kelso, L Gu - BioMed research international, 2015 - Wiley Online Library
The closed head impact (CHI) rat models are commonly used for studying the traumatic
brain injury. The impact parameters vary considerably among different laboratories, making …