The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
Neuroimaging in dementia
SL Risacher, LG Apostolova - CONTINUUM: Lifelong Learning in …, 2023 - journals.lww.com
OBJECTIVE Neurodegenerative diseases are significant health concerns with regard to
morbidity and social and economic hardship around the world. This review describes the …
morbidity and social and economic hardship around the world. This review describes the …
Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum
Tau phosphorylated at threonine 181 (p-tau181) measured in blood plasma has recently
been proposed as an accessible, scalable, and highly specific biomarker for Alzheimer's …
been proposed as an accessible, scalable, and highly specific biomarker for Alzheimer's …
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography
Advances in molecular positron emission tomography (PET) have enabled anatomic
tracking of brain pathology in longitudinal studies of normal aging and dementia, including …
tracking of brain pathology in longitudinal studies of normal aging and dementia, including …
[HTML][HTML] Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia
We describe in vivo follow-up PET imaging and postmortem findings from an autosomal
dominant Alzheimer's disease (ADAD) PSEN1 E280A carrier who was also homozygous for …
dominant Alzheimer's disease (ADAD) PSEN1 E280A carrier who was also homozygous for …
Predicting amyloid PET and tau PET stages with plasma biomarkers
CR Jack Jr, HJ Wiste, A Algeciras-Schimnich… - Brain, 2023 - academic.oup.com
Staging the severity of Alzheimer's disease pathology using biomarkers is useful for
therapeutic trials and clinical prognosis. Disease staging with amyloid and tau PET has face …
therapeutic trials and clinical prognosis. Disease staging with amyloid and tau PET has face …
Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals
FZ Lussier, TA Pascoal, M Chamoun… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Mild behavioral impairment (MBI) is characterized by the emergence of
neuropsychiatric symptoms in elderly persons. Here, we examine the associations between …
neuropsychiatric symptoms in elderly persons. Here, we examine the associations between …
Spatial-temporal patterns of β-amyloid accumulation: a subtype and stage inference model analysis
Background and Objectives β-amyloid (Aβ) staging models assume a single spatial-
temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation …
temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation …
Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease
E Guzmán-Vélez, I Diez… - Proceedings of the …, 2022 - National Acad Sciences
The human brain is composed of functional networks that have a modular topology, where
brain regions are organized into communities that form internally dense (segregated) and …
brain regions are organized into communities that form internally dense (segregated) and …
Multitracer model for staging cortical amyloid deposition using PET imaging
Objective To develop and evaluate a model for staging cortical amyloid deposition using
PET with high generalizability. Methods Three thousand twenty-seven individuals (1,763 …
PET with high generalizability. Methods Three thousand twenty-seven individuals (1,763 …