Cancer remains a leading cause of death worldwide due to the lack of safer and more
effective therapies. Cancer vaccines developed from neoantigens are an emerging strategy …

For early detection of cancer, education and screening are important, but the most critical
factor is the development of early diagnostic tools. Methods that recognize the warning signs …

Tumor-associated carbohydrate antigens (TACAs) support cell survival that could be
interrupted by anti-TACA antibodies. Among TACAs that mediate cell survival signals are the …

The promise of idiotype-based therapeutics has been disappointing forcing a new look at
the concept and its potential to generate an effective approach for immunotherapy. Here, the …

Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed
and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our …

Mimotopes are epitope-mimicking structures. When applied for immunizations they induce
desired antibody specificities exclusively based on the principle of molecular mimicry. This is …

A basic tenet of antibody-based immunity is their specificity to antigenic determinates from
foreign pathogen products to abnormal cellular components such as in cancer. However, an …

Molecular mimicry is fundamental to biology and transcends to many disciplines ranging
from immune pathology to drug design. Structural characterization of molecular partners has …

Background We previously reported a limb-salvage technique by treating tumor-bearing
bone with liquid nitrogen. We also reported systemic antitumor immunity was enhanced by …

Tumor-Associated Carbohydrate Antigens (TACAs) are broad-spectrum targets for
immunotherapy. Immunization with Carbohydrate Mimetic Peptides (CMPs) is a strategy to …