Brain temperature: physiology and pathophysiology after brain injury

S Mrozek, F Vardon, T Geeraerts - … research and practice, 2012 - Wiley Online Library
The regulation of brain temperature is largely dependent on the metabolic activity of brain
tissue and remains complex. In intensive care clinical practice, the continuous monitoring of …

[PDF][PDF] Mechanisms of fever production and lysis: lessons from experimental LPS fever

J Roth, CM Blatteis - Compr Physiol, 2014 - researchgate.net
Fever is a cardinal symptom of infectious or inflammatory insults, but it can also arise from
noninfectious causes. The fever-inducing agent that has been used most frequently in …

[PDF][PDF] Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders

C Mancuso, G Scapagini, D Currò, AM Giuffrida Stella… - Front Biosci, 2007 - Citeseer
[Frontiers in Bioscience 12, 1107-1123, January 1, 2007] 1107 Mitochondrial dysfunction, free
radical generation and cellular st Page 1 [Frontiers in Bioscience 12, 1107-1123, January 1 …

Versatile Ti3C2Tx MXene for free-radical scavenging

J Liu, W Lu, X Lu, L Zhang, H Dong, Y Li - Nano Research, 2022 - Springer
MXene, as an emerging two-dimensional (2D) material with ultrathin structure and
fascinating physiochemical properties, has been widely explored in broad applications …

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation

E Barone, F Di Domenico, C Mancuso… - Neurobiology of …, 2014 - Elsevier
Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. These clinical features are due …

Hypoxia-induced anapyrexia: implications and putative mediators

AA Steiner, LGS Branco - Annual Review of Physiology, 2002 - annualreviews.org
▪ Abstract Hypoxia elicits an array of compensatory responses in animals ranging from
protozoa to mammals. Central among these responses is anapyrexia, the regulated …

Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic–pituitary–adrenal axis

C Mancuso, P Navarra, P Preziosi - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 113, 563–575. Abstract The importance of stress in modifying human
behavior and lifestyle is no longer a matter of debate. Although mild stress enhances the …

Heme oxygenase and its products in the nervous system

C Mancuso - Antioxidants & redox signaling, 2004 - liebertpub.com
Heme oxygenase (HO) cleaves the tetrapyrrolic ring of cellular heme moieties liberating
carbon monoxide (CO) and equimolar amounts of free iron and biliverdin (BV). BV is in turn …

The heme oxygenase/biliverdin reductase pathway in drug research and development

C Mancuso, E Barone - Current drug metabolism, 2009 - ingentaconnect.com
The heme oxygenase/biliverdin reductase (HO/BVR) axis catalyzes the degradation of
heme, but this system and its byproducts, carbon monoxide (CO) and bilirubin, have also …

Biliverdin as a disease-modifying agent: An integrated viewpoint

C Mancuso - Free Radical Biology and Medicine, 2023 - Elsevier
Biliverdin is one of the three by-products of heme oxygenase (HO) activity, the others being
ferrous iron and carbon monoxide. Under physiological conditions, once formed in the cell …