The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …

Benign prostate hyperplasia (BPH), one of the most common diseases in older men,
adversely affects quality-of-life due to the presence of low urinary tract symptoms (LUTS) …

Steroid hormones regulate a wide variety of physiological and developmental functions.
Traditional steroid hormone signaling acts through nuclear and cytosolic receptors, altering …

Gynecomastia—the enlargement of male breast tissue in men—is a common finding,
frequently observed in newborns, adolescents, and old men. Physiological gynecomastia …

Obesity is a new risk factor, to which more and more research is devoted, related to the
development of cancer. Many studies of recent years have drawn attention to the role of …

Existing epidemiologic and clinical studies have demonstrated that obesity is associated
with the risk of a variety of cancers. In recent years, an increasing number of experimental …

Adipose tissue is part of the prostate cancer (PCa) microenvironment not only in the
periprostatic area, but also in the most frequent metastatic sites, such as bone marrow and …

The prevalence of global obesity is increasing. Obesity is associated with general cancer-
related morbidity and mortality and is a known risk factor for development of specific …

The steroid submetabolome, or steroidome, is of particular interest in prostate cancer (PCa)
as the dependence of PCa growth on androgens is well known and has been routinely …

Despite the discovery of a large number of anticancer agents, cancer still remains among
the leading causes of death since the middle of the twentieth century. Solid tumors possess …