Review of mathematical modeling of the inflammatory response in lung infections and injuries

SB Minucci, RL Heise, AM Reynolds - Frontiers in Applied …, 2020 - frontiersin.org
Lung inflammation may occur due to viral and bacterial infections, structural damage, or
inhalation of dangerous particles. These injuries may be quickly resolved by the immune …

Mathematical Modeling of COVID-19 dynamics under two vaccination doses and delay effects

G Sepulveda, AJ Arenas, G González-Parra - Mathematics, 2023 - mdpi.com
The aim of this paper is to investigate the qualitative behavior of the COVID-19 pandemic
under an initial vaccination program. We constructed a mathematical model based on a …

Modeling recapitulates the heterogeneous outcomes of SARS-CoV-2 infection and quantifies the differences in the innate immune and CD8 T-cell responses between …

B Chatterjee, H Singh Sandhu, NM Dixit - PLoS pathogens, 2022 - journals.plos.org
SARS-CoV-2 infection results in highly heterogeneous outcomes, from cure without
symptoms to acute respiratory distress and death. Empirical evidence points to the …

Modelling of the innate and adaptive immune response to SARS viral infection, cytokine storm and vaccination

C Leon, A Tokarev, A Bouchnita, V Volpert - Vaccines, 2023 - mdpi.com
In this work, we develop mathematical models of the immune response to respiratory viral
infection, taking into account some particular properties of the SARS-CoV infections …

Predicting the kinetic coordination of immune response dynamics in SARS-CoV-2 infection: implications for disease pathogenesis

D Grebennikov, A Karsonova, M Loguinova, V Casella… - Mathematics, 2022 - mdpi.com
A calibrated mathematical model of antiviral immune response to SARS-CoV-2 infection is
developed. The model considers the innate and antigen-specific responses to SARS-CoV-2 …

Global stability of a humoral immunity COVID-19 model with logistic growth and delays

AM Elaiw, AJ Alsaedi, AD Al Agha, AD Hobiny - Mathematics, 2022 - mdpi.com
The mathematical modeling and analysis of within-host or between-host coronavirus
disease 2019 (COVID-19) dynamics are considered robust tools to support scientific …

Immune response to SARS-CoV-2 in severe disease and long COVID-19

T Sumi, K Harada - Iscience, 2022 - cell.com
COVID-19 is mild to moderate in otherwise healthy individuals but may nonetheless cause
life-threatening disease and/or a wide range of persistent symptoms. The general …

Understanding dynamics of pandemic models to support predictions of COVID-19 transmission: parameter sensitivity analysis of SIR-type models

C Ma, X Li, Z Zhao, F Liu, K Zhang… - IEEE Journal of …, 2022 - ieeexplore.ieee.org
Despite efforts made to model and predict COVID-19 transmission, large predictive
uncertainty remains. Failure to understand the dynamics of the nonlinear pandemic …

Global Stability of a reaction–diffusion malaria/COVID-19 coinfection dynamics model

AM Elaiw, AD Al Agha - Mathematics, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new virus which infects
the respiratory system and causes the coronavirus disease 2019 (COVID-19). The …

Computational simulations to dissect the cell immune response dynamics for severe and critical cases of SARS-CoV-2 infection

R Blanco-Rodriguez, X Du… - Computer methods and …, 2021 - Elsevier
Background: COVID-19 is a global pandemic leading to high death tolls worldwide day by
day. Clinical evidence suggests that COVID-19 patients can be classified as non-severe …