Tumor‐microenvironment‐responsive nanomedicine for enhanced cancer immunotherapy
The past decades have witnessed great progress in cancer immunotherapy, which has
profoundly revolutionized oncology, whereas low patient response rates and potential …
profoundly revolutionized oncology, whereas low patient response rates and potential …
[HTML][HTML] Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
Y Xu, J Xiong, X Sun, H Gao - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cancer immunotherapy has significantly flourished and revolutionized the limited
conventional tumor therapies, on account of its good safety and long-term memory ability …
conventional tumor therapies, on account of its good safety and long-term memory ability …
Smart transformable nanoparticles for enhanced tumor theranostics
The physical morphologies of nanoparticles, especially size and shape, always significantly
influence their biological behaviors. In the past, nanoparticles with constant physical …
influence their biological behaviors. In the past, nanoparticles with constant physical …
Biomimetic diselenide‐bridged mesoporous organosilica nanoparticles as an X‐ray‐responsive biodegradable carrier for chemo‐immunotherapy
Chemotherapy causes off‐target toxicity and is often ineffective against solid tumors.
Targeted and on‐demand release of chemotherapeutics remains a challenge. Here, cancer …
Targeted and on‐demand release of chemotherapeutics remains a challenge. Here, cancer …
Smart and bioinspired systems for overcoming biological barriers and enhancing disease theranostics
Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …
Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction
J Xu, J Zhang, Z Zhang, Z Gao, Y Qi, W Qiu, Z Pan… - Cell Death & …, 2021 - nature.com
Exosomes participate in intercellular communication and glioma microenvironment
modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote …
modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote …
Trident molecule with nanobrush–nanoparticle–nanofiber transition property spatially suppresses tumor metastasis
Metastasis-induced high mortality of cancers urgently demands new approaches to
simultaneously inhibit primary tumor metastasis and distant tumor growth. Herein, by rational …
simultaneously inhibit primary tumor metastasis and distant tumor growth. Herein, by rational …
The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor
W Xiao, Y Wang, H Zhang, Y Liu, R Xie, X He, Y Zhou… - Biomaterials, 2021 - Elsevier
The modification of targeting ligands on nanoparticles (NPs) is anticipated to enhance the
delivery of therapeutics to diseased tissues. However, once exposed to the blood stream …
delivery of therapeutics to diseased tissues. However, once exposed to the blood stream …
Designer exosomes enabling tumor targeted efficient chemo/gene/photothermal therapy
Abstract Exosomes, endogenous nanosized particles (50–150 nm) secreted and absorbed
by cells, have been recently used as diagnostic and therapeutic platforms in cancer …
by cells, have been recently used as diagnostic and therapeutic platforms in cancer …
[HTML][HTML] Targeting regulated cell death in tumor nanomedicines
Nanomedicines hold great potential in anticancer therapy by modulating the biodistribution
of nanomaterials and initiating targeted oxidative stress damage, but they are also limited by …
of nanomaterials and initiating targeted oxidative stress damage, but they are also limited by …