Oxidative stress and resulting lipid peroxidation is involved in various and numerous
pathological states including inflammation, atherosclerosis, neurodegenerative diseases …

Polyunsaturated fatty acids are susceptible to peroxidation and they yield various
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …

This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross …

Peroxidative degradation of lipids yields the aldehyde 4-hydroxy-2-nonenal (4HNE) as a
major product. The lipid aldehyde is an electrophile, and reactivity of 4HNE toward protein …

Multidrug resistance–associated proteins (Mrps) are adenosine triphosphate–dependent
transporters that efflux chemicals out of cells. In the liver, Mrp2 transports bilirubin …

The human placenta fulfills a variety of essential functions during prenatal life. Several ABC
transporters are expressed in the human placenta, where they play a role in the transport of …

Hydroxynonenal (HNE), an electrophilic end-product deriving from lipid peroxidation,
undergoes a heterogeneous set of biotransformations including enzymatic and non …

hydroxy-2-nonenal (HNE) is an amazing reactive compound, originating from lipid
peroxidation within cells but also in food and considered as a “second messenger” of …

Drug-metabolizing enzymes and membrane transporters are responsible for the
detoxication and elimination of xenobiotics from the body. The goal of this study was to …

Perfluorooctanoic acid and perfluorodecanoic acid (PFDA) are commonly used as
emulsifiers and surfactants in fluoropolymer manufacturing and are known peroxisome …