Protein misfolding in the endoplasmic reticulum as a conduit to human disease
M Wang, RJ Kaufman - Nature, 2016 - nature.com
In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of
proteins that enter the secretory pathway. Environmental insults or increased protein …
proteins that enter the secretory pathway. Environmental insults or increased protein …
Coping with stress: eIF2 kinases and translational control
RC Wek, HY Jiang, TG Anthony - Biochemical Society …, 2006 - portlandpress.com
In response to environmental stresses, a family of protein kinases phosphorylate eIF2
(eukaryotic initiation factor 2) to alleviate cellular injury or alternatively induce apoptosis …
(eukaryotic initiation factor 2) to alleviate cellular injury or alternatively induce apoptosis …
ER chaperone functions during normal and stress conditions
Y Ma, LM Hendershot - Journal of chemical neuroanatomy, 2004 - Elsevier
Nearly all resident proteins of the organelles along the secretory pathway, as well as
proteins that are expressed at the cell surface or secreted from the cell, are first co …
proteins that are expressed at the cell surface or secreted from the cell, are first co …
Endoplasmic reticulum (ER) stress and its role in pancreatic β-cell dysfunction and senescence in type 2 diabetes
JH Lee, J Lee - International journal of molecular sciences, 2022 - mdpi.com
An increased life span and accompanying nutritional affluency have led to a rapid increase
in diseases associated with aging, such as obesity and type 2 diabetes, imposing a …
in diseases associated with aging, such as obesity and type 2 diabetes, imposing a …
A WNT4 Mutation Associated with Müllerian-Duct Regression and Virilization in a 46,XX Woman
A Biason-Lauber, D Konrad, F Navratil… - New England Journal …, 2004 - Mass Medical Soc
WNT4, a secreted protein that suppresses male sexual differentiation, is thought to repress
the biosynthesis of gonadal androgen in female mammals. An 18-year-old woman …
the biosynthesis of gonadal androgen in female mammals. An 18-year-old woman …
Endoplasmic reticulum stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2
A Saito, K Ochiai, S Kondo, K Tsumagari… - Journal of biological …, 2011 - ASBMB
To avoid excess accumulation of unfolded proteins in the endoplasmic reticulum (ER),
eukaryotic cells have signaling pathways from the ER to the cytosol or nucleus. These …
eukaryotic cells have signaling pathways from the ER to the cytosol or nucleus. These …
eIF2 and the control of cell physiology
CG Proud - Seminars in cell & developmental biology, 2005 - Elsevier
Eukaryotic initiation factor eIF2 and its 'exchange factor'eIF2B play a key role in the
regulation of protein synthesis in eukaryotes from yeast to mammals. Phosphorylation of …
regulation of protein synthesis in eukaryotes from yeast to mammals. Phosphorylation of …
Neonatal diabetes mellitus
L Aguilar-Bryan, J Bryan - Endocrine reviews, 2008 - academic.oup.com
An explosion of work over the last decade has produced insight into the multiple hereditary
causes of a nonimmunological form of diabetes diagnosed most frequently within the first 6 …
causes of a nonimmunological form of diabetes diagnosed most frequently within the first 6 …
Diabetes and Insulin Secretion: The ATP-Sensitive K+ Channel (KATP) Connection
JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc
The ATP-sensitive K+ channel (KATP channel) senses metabolic changes in the pancreatic
β-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion …
β-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion …
PERK pathway and neurodegenerative disease: to inhibit or to activate?
T Shacham, C Patel, GZ Lederkremer - Biomolecules, 2021 - mdpi.com
With the extension of life span in recent decades, there is an increasing burden of late-onset
neurodegenerative diseases, for which effective treatments are lacking. Neurodegenerative …
neurodegenerative diseases, for which effective treatments are lacking. Neurodegenerative …