Mitochondria as a target of environmental toxicants

JN Meyer, MCK Leung, JP Rooney… - toxicological …, 2013 - academic.oup.com
Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …

Perfluoroalkyl acids: a review of monitoring and toxicological findings

C Lau, K Anitole, C Hodes, D Lai… - Toxicological …, 2007 - academic.oup.com
In recent years, human and wildlife monitoring studies have identified perfluoroalkyl acids
(PFAA) worldwide. This has led to efforts to better understand the hazards that may be …

The developmental toxicity of perfluoroalkyl acids and their derivatives

C Lau, JL Butenhoff, JM Rogers - Toxicology and applied pharmacology, 2004 - Elsevier
Perfluoroalkyl acids such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid
(PFOA) have applications in numerous industrial and consumer products. Although the …

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

KP Das, CR Wood, MT Lin, AA Starkov, C Lau… - Toxicology, 2017 - Elsevier
Persistent presence of perfluoroalkyl acids (PFAAs) in the environment is due to their
extensive use in industrial and consumer products, and their slow decay. Biochemical tests …

The toxicology of perfluorooctanoate

GL Kennedy, JL Butenhoff, GW Olsen… - Critical reviews in …, 2004 - Taylor & Francis
ABSTRACT PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological
and biochemical effects characteristic of PPAR agonists. These effects include increased β …

Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation

C Lau, JR Thibodeaux, RG Hanson… - Toxicological …, 2003 - academic.oup.com
The postnatal effects of in utero exposure to perfluorooctane sulfonate (PFOS, C8F17SO3−)
were evaluated in the rat and mouse. Pregnant Sprague-Dawley rats were given 1, 2, 3, 5 …

Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys

AM Seacat, PJ Thomford, KJ Hansen… - Toxicological …, 2002 - academic.oup.com
This study was conducted to determine the earliest measurable response of primates to low-
level perfluorooctanesulfonate (PFOS) exposure and to provide information to reduce …

Occurrence and persistence of perfluorooctanesulfonate and other perfluorinated surfactants in groundwater at a fire-training area at Wurtsmith Air Force Base …

CA Moody, GN Hebert, SH Strauss… - Journal of Environmental …, 2003 - pubs.rsc.org
Various formulations of fire-extinguishing materials, including aqueous film-forming foams
(AFFFs), were used as part of fire-training exercises conducted at Wurtsmith Air Force Base …

Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations

JR Thibodeaux, RG Hanson, JM Rogers… - Toxicological …, 2003 - academic.oup.com
The maternal and developmental toxicities of perfluorooctane sulfonate (PFOS,
C8F17SO3−) were evaluated in the rat and mouse. PFOS is an environmentally persistent …

Aquatic toxicology of perfluorinated chemicals

DM Whitacre, JP Giesy, JE Naile, JS Khim… - Reviews of …, 2010 - Springer
Perfluorinated compounds (PFCs) are fluorinated at all of the valence electrons of the
carbon atoms in organic molecules, or at least a portion of the molecule is perfluorinated …