Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Background: The proliferation of computerized neuropsychological assessment devices
(CNADs) for screening and monitoring cognitive impairment is increasing exponentially …

Background Although several disease-modifying treatments are available for relapsing
multiple sclerosis, treatment effects have been more modest in progressive multiple …

Background: The need for more robust outcomes in multiple sclerosis (MS) clinical trials has
been a main priority of the field for decades. Dissatisfaction with existing measures has led …

Objective To investigate the effects of siponimod on cognitive processing speed in patients
with secondary progressive (SP) multiple sclerosis (MS), by means of a predefined …

Machine learning (ML) approaches have demonstrated promising results in a wide range of
healthcare applications. Data plays a crucial role in developing ML-based healthcare …

Objective We report analyses of a pooled database by the Multiple Sclerosis Outcome
Assessments Consortium to evaluate 4 proposed components of a multidimensional test …

Background: The timed 25-foot walk (T25FW) is a key clinical outcome measure in multiple
sclerosis patient management and clinical research. Objectives: To evaluate T25FW …

Background: Cognitive impairment is common in multiple sclerosis (MS) but its manifestation
as acute disease activity is underappreciated. Objective: The aim of this study is to examine …

Accumulating neurological disability has a substantial impact on the lives of patients with
multiple sclerosis (MS). As well as the established Expanded Disability Status Scale (EDSS) …