Bacteriophages, the most abundant organisms on earth, have the potential to address the
rise of multidrug-resistant bacteria resulting from the overuse of antibiotics. However, their …

Facing the global “superbug” crisis due to the emergence and selection for antibiotic
resistance, phages are among the most promising solutions. Fighting multidrug-resistant …

The discovery of clustered, regularly interspaced, short palindromic repeats (CRISPR) and
the Cas9 RNA-guided nuclease provides unprecedented opportunities to selectively kill …

ABSTRACT The Burkholderia cepacia complex (Bcc) causes life-threatening respiratory
tract infections in persons with cystic fibrosis (CF). In CF patients, end-stage pulmonary …

Antibiotic failure is one of the most worrisome threats to global health. Among the new
therapeutic efforts that are being explored, the use of bacteriophages (viruses that kill …

Introduction Bacterial synthetic biology has provided powerful tools to revolutionize the drug
discovery process. These tools can be harnessed to generate bacterial novel …

The discovery of antibiotics has fully changed medicinal therapy. However, with the
increased therapeutic use of antibiotics, bacteria continued to develop mechanisms to resist …

Bacteriophages use receptor-binding proteins (RBPs) to adhere to bacterial hosts.
Understanding the structure of these RBPs can provide insights into their target interactions …

Bacteriophages have immense potential for applications in fields such as phage therapy
and microbiome engineering. Synthetic biology approaches can be used to generate …

Despite improvements in cancer treatments, there is still an unmet clinical need for effective
therapeutic agents that are highly tumour specific. Oncolytic viruses hold many …