Background s troke is the main cause of disability in high-income countries, and ranks
second as a cause of death worldwide. Patients with acute stroke are at risk for infections …

Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

Purpose—The aim of this statement is to present current and comprehensive
recommendations for the diagnosis and treatment of acute spontaneous intracerebral …

Purpose—The purpose of this statement is to review the literature on childhood stroke and to
provide recommendations for optimal diagnosis and treatment. This statement is intended …

Increasing evidence suggests that induction of mild hypothermia (32–35° C) in the first hours
after an ischaemic event can prevent or mitigate permanent injuries. This effect has been …

Introduction Restoration of blood flow following ischemic stroke can be achieved by means
of thrombolysis or mechanical recanalization. However, for some patients, reperfusion may …

This article represents the update of 'European Stroke Initiative Recommendations for Stroke
Management', first published in this Journal in 2000. The recommendations are endorsed by …

Neuroprotection seeks to restrict injury to the brain parenchyma following an ischaemic
insult by preventing salvageable neurons from dying. The concept of neuroprotection has …

Induced hypothermia can be used to protect the brain from post-ischemic and traumatic
neurological injury. Potential clinical applications and the available evidence are discussed …

Cerebral ischemia leads to brain damage caused by pathogenetic mechanisms that are also
activated by neurotrauma. These mechanisms include among others excitotoxicity, over …