The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are
being developed every year, making it vital to find a non-invasive route such as nasal or …

We are accumulating evidence that intestinal microflora, collectively named gut microbiota,
can alter brain pathophysiology, but researchers have just begun to discover the …

Blood‐brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic
substance in and out of the central nervous system (CNS), and plays a crucial role in …

The societal need for new central nervous system (CNS) medicines is substantial, because
of the global increase in life expectancy and the accompanying increase in age-related CNS …

The most important obstacle to the drug delivery into the brain is the presence of the blood–
brain barrier, which limits the traffic of substances between the blood and the nervous tissue …

Previous studies have shown that modulation of the receptor-mediated cannabinoid system
during neuroinflammation can produce potent neuroprotective and anti-inflammatory effects …

Abstract Three-dimensional (3D) tissue-engineered models of the blood-brain barrier (BBB)
recapitulate in vivo shear stress, cylindrical geometry, and cell-ECM interactions. Here we …

Metastatic brain tumours are frequently observed in patients with lung, breast and malignant
melanoma and a severe complication of metastatic cancers. With improved primary cancer …

During the past few decades of astrocyte research it has become increasingly clear that
astrocytes have taken a central position in all central nervous system activities. Much of our …