Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

The possibility of safe discontinuation of therapy with nucleos (t) ide analogues (NAs)
remains one of the most controversial topics in the management of chronic hepatitis B …

ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins discovered
nearly six decades ago, but many important questions remain regarding its molecular …

Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …

Resistance to androgen deprivation therapy, or castration-resistant prostate cancer (CRPC),
is often accompanied by metastasis and is currently the ultimate cause of prostate cancer …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …

The intracellular ATP-ribosyltransferases PARP1 and PARP2, contribute to DNA base
excision repair (BER) and DNA demethylation and have been implicated in epigenetic …

In 1963, Chambon et al. reported the detection of a nicotinamide mononucleotide-activated,
DNA-dependent enzymatic activity in rat liver extracts that catalyzed the synthesis of a …

Progressive familial intrahepatic cholestasis type 3 is caused by biallelic variations of
ABCB4, most often (≥ 70%) missense. In this study, we examined the effects of 12 missense …

The authors show that increased poly (adenosine diphosphate–ribose) polymerase 1
(PARP1) and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of …