Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder that has both
adverse reproductive and metabolic implications for affected women. However, there is …

BACKGROUND Androgens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are
essential in human ovarian folliculogenesis. However, the interactions between these four …

Although hormonal regulation of ovarian follicle development has been extensively
investigated, most studies concentrate on the development of early antral follicles to the …

Androgens and estrogens are known to be critical regulators of mammalian physiology and
development. While these two classes of steroids share similar structures (in general …

Steroid hormone receptors mediate numerous crucial biological processes and are
classically thought to function as transcriptional regulators in the nucleus. However, it has …

Recent studies challenge the previous view that apoptosis within the granulosa cells of the
maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of …

The major goal of this review is to summarize recent exciting findings that have been
published within the past 10 years that, to our knowledge, have not been presented in detail …

Androgens in women, as well as in men, are intrinsic to maintenance of (i) reproductive
competency,(ii) cardiac health,(iii) appropriate bone remodeling and mass retention,(iii) …

Background Genetic, environmental and epigenetical factors may play important roles in the
pathogenesis of polycystic ovary syndrome (PCOS), however the etiology of PCOS remains …

MicroRNAs (miRNAs) are active regulators of numerous biological and physiological
processes including most of the events of mammalian reproduction. Understanding the …