Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown,
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …

For more than a century, research on psychopathology has focused on categorical
diagnoses. Although this work has produced major discoveries, growing evidence points to …

Large-scale sequencing has enabled unparalleled opportunities to investigate the role of
rare coding variation in human phenotypic variability. Here, we present a pan-ancestry …

Anxiety disorders are the most prevalent mental disorders. However, the genetic etiology of
anxiety disorders remains largely unknown. Here we conducted a genome-wide meta …

Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal
phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven …

Background Suicide is a major issue for global public health. Suicidality describes a broad
spectrum of thoughts and behaviours, some of which are common in the general population …

Abstract Major Depressive Disorder (MDD) often is associated with significant cognitive
dysfunction. We conducted a meta-analysis of genome-wide interaction of MDD and …

Major depressive disorder (MDD) is phenotypically associated with cardiovascular diseases
(CVD). We aim to investigate mechanisms underlying relationships between MDD and CVD …

Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

Chronic pain is often present at more than one anatomical location, leading to chronic
overlapping pain conditions. Whether chronic overlapping pain conditions represent a …