Why hasn't there been more progress in new Chagas disease drug discovery?
AB Vermelho, GC Rodrigues… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …
Advances in schistosomiasis drug discovery based on natural products.
Schistosomiasis is a neglected tropical disease affecting over 250 million people worldwide.
The disease is the second most prevalent neglected tropical disease after malaria …
The disease is the second most prevalent neglected tropical disease after malaria …
[HTML][HTML] In silico approaches to develop herbal acaricides against R.(Boophilus) microplus and In vitro Anti-Tick activities of selected medicinal plants
In tropical and sub-tropical areas of the world the most damaging pest of the livestock sector
are cattle tick, Rhipicephalus microplus. The current study was aimed to generate …
are cattle tick, Rhipicephalus microplus. The current study was aimed to generate …
[HTML][HTML] In Vivo Evaluation of the Anti-Schistosomal Potential of Ginger-Loaded Chitosan Nanoparticles on Schistosoma mansoni: Histopathological, Ultrastructural …
MM El-Derbawy, HS Salem, M Raboo, IR Baiuomy… - Life, 2022 - mdpi.com
Chemotherapy is the most widely advocated method of Schistosome control. However,
repeated chemotherapy leads to the emergence of drug-resistant Schistosoma strains …
repeated chemotherapy leads to the emergence of drug-resistant Schistosoma strains …
[HTML][HTML] A novel glutathione-S-transferase-based biosensor for pyrethroid insecticides: From inhibition study to detection
In this study, the inhibitory potential of four pyrethroid compounds on glutathione S-
transferase (GST) by using molecular docking and in vitro assays was evaluated. Docking …
transferase (GST) by using molecular docking and in vitro assays was evaluated. Docking …
[HTML][HTML] Quantitative Structure–Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity
Small-molecule compounds that have promising activity against macromolecular targets
from Trypanosoma cruzi occasionally fail when tested in whole-cell phenotypic assays. This …
from Trypanosoma cruzi occasionally fail when tested in whole-cell phenotypic assays. This …
Exploring Novel Antimalarial Compounds Targeting Plasmodium falciparum Enoyl-ACP Reductase: Computational and Experimental Insights
G AR Oliveira, B GDV Morales, R MO Sousa… - ACS …, 2024 - ACS Publications
Malaria, caused by Plasmodium protozoa with Plasmodium falciparum as the most virulent
species, continues to pose significant health challenges. Despite the availability of effective …
species, continues to pose significant health challenges. Despite the availability of effective …
Limonene and perillyl alcohol derivatives: Synthesis and anticancer activity
CEH da Silva, G Gosmann… - Mini Reviews in …, 2021 - ingentaconnect.com
Limonene and perillyl alcohol are natural monoterpenes that have attracted the attention of
medicinal chemists due to their promising anticancer activities. Considering this, both …
medicinal chemists due to their promising anticancer activities. Considering this, both …
Diaminomaleonitrile derivatives as new potential antichagasic compounds: a study of structure–activity relationships
AS de Oliveira, LS Mello, CH Ogihara… - Future Medicinal …, 2021 - Taylor & Francis
Background: Schiff bases are synthetically accessible compounds that have been used in
medicinal chemistry. Methods & results: In this work, 27 Schiff bases derived from …
medicinal chemistry. Methods & results: In this work, 27 Schiff bases derived from …
[HTML][HTML] First Description of Marinoquinoline Derivatives' Activity against Toxoplasma gondii
LTH Diethelm, ABSB Ramos, GB de Lorena, BI Trajano… - Pharmaceutics, 2024 - mdpi.com
Toxoplasmosis is a globally prevalent zoonotic disease with significant clinical implications,
including neurotoxoplasmosis, a leading cause of cerebral lesions in AIDS patients. The …
including neurotoxoplasmosis, a leading cause of cerebral lesions in AIDS patients. The …