Role of proteasomes in inflammation
CC Goetzke, F Ebstein, T Kallinich - Journal of clinical medicine, 2021 - mdpi.com
The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …
Site-specific proteasome inhibitors
AF Kisselev - Biomolecules, 2021 - mdpi.com
Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …
Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway
XY Chen, SF Wan, NN Yao, ZJ Lin, YG Mao… - Military Medical …, 2021 - Springer
Background Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain
injury and neurological impairment. Previous work confirmed the involvement of the …
injury and neurological impairment. Previous work confirmed the involvement of the …
On the role of the immunoproteasome in protein homeostasis
M Basler, M Groettrup - Cells, 2021 - mdpi.com
Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …
Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits
J Zhou, C Li, M Lu, G Jiang, S Chen, H Li, K Lu - Plos Biology, 2024 - journals.plos.org
Defective autophagy is linked to proinflammatory diseases. However, the mechanisms by
which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR …
which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR …
LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis
S Li, RC He, SG Wu, Y Song, KL Zhang… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Increasing evidence suggests that long noncoding RNAs play significant
roles in vascular biology and disease development. One such long noncoding RNA, PSMB8 …
roles in vascular biology and disease development. One such long noncoding RNA, PSMB8 …
Structure-based optimization and discovery of M3258, a specific inhibitor of the immunoproteasome subunit LMP7 (β5i)
M Klein, M Busch, M Friese-Hamim… - Journal of medicinal …, 2021 - ACS Publications
Proteasomes are broadly expressed key components of the ubiquitin-dependent protein
degradation pathway containing catalytically active subunits (β1, β2, and β5). LMP7 (β5i) is …
degradation pathway containing catalytically active subunits (β1, β2, and β5). LMP7 (β5i) is …
Discovery and early clinical development of selective immunoproteasome inhibitors
CJ Kirk, T Muchamuel, J Wang, RA Fan - Cells, 2021 - mdpi.com
Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of
multiple B-cell malignancies. These agents have also been employed with success in the …
multiple B-cell malignancies. These agents have also been employed with success in the …
Targeted Transcriptomic Analysis of C57BL/6 and BALB/c Mice During Progressive Chronic Toxoplasma gondii Infection Reveals Changes in Host and Parasite …
KV Bergersen, A Barnes, D Worth, C David… - Frontiers in Cellular …, 2021 - frontiersin.org
Toxoplasma gondii is a resilient parasite that infects a multitude of warm-blooded hosts and
results in a lifelong chronic infection requiring continuous responses by the host. Chronic …
results in a lifelong chronic infection requiring continuous responses by the host. Chronic …
Recent insights how combined inhibition of immuno/proteasome subunits enables therapeutic efficacy
M Basler, M Groettrup - Genes & Immunity, 2020 - nature.com
The proteasome is a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells
that controls numerous cellular processes through regulated protein degradation …
that controls numerous cellular processes through regulated protein degradation …