[HTML][HTML] A systematic review on the usage of averaged LET in radiation biology for particle therapy

F Kalholm, L Grzanka, E Traneus, N Bassler - Radiotherapy and Oncology, 2021 - Elsevier
Abstract Linear Energy Transfer (LET) is widely used to express the radiation quality of ion
beams, when characterizing the biological effectiveness. However, averaged LET may be …

“Radiobiology of Proton Therapy”: Results of an international expert workshop

A Lühr, C von Neubeck, J Pawelke, A Seidlitz… - Radiotherapy and …, 2018 - Elsevier
The physical properties of proton beams offer the potential to reduce toxicity in tumor-
adjacent normal tissues. Toward this end, the number of proton radiotherapy facilities has …

Relative biological effectiveness (RBE) and distal edge effects of proton radiation on early damage in vivo

BS Sørensen, N Bassler, S Nielsen, MR Horsman… - Acta …, 2017 - Taylor & Francis
Introduction: The aim of the present study was to examine the RBE for early damage in an in
vivo mouse model, and the effect of the increased linear energy transfer (LET) towards the …

Challenges in Monte Carlo simulations as clinical and research tool in particle therapy: a review

S Muraro, G Battistoni, AC Kraan - Frontiers in Physics, 2020 - frontiersin.org
The use and interest in Monte Carlo (MC) techniques in the field of medical physics have
been rapidly increasing in the past years. This is the case especially in particle therapy …

Development and validation of proton track-structure model applicable to arbitrary materials

T Ogawa, Y Hirata, Y Matsuya, T Kai - Scientific Reports, 2021 - nature.com
A novel transport algorithm performing proton track-structure calculations in arbitrary
materials was developed. Unlike conventional algorithms, which are based on the dielectric …

GATE‐RTion: a GATE/Geant4 release for clinical applications in scanned ion beam therapy

L Grevillot, DJ Boersma, H Fuchs… - Medical …, 2020 - Wiley Online Library
Purpose GATE‐RTion is a validated version of GATE for clinical use in the field of light ion
beam therapy. This paper describes the GATE‐RTion project and illustrates its potential …

Energy-dependent fragmentation cross sections of relativistic

T Ogawa, T Sato, S Hashimoto, D Satoh, S Tsuda… - Physical Review C, 2015 - APS
The fragment production excitation functions of C 12 interacting with carbon nuclei were
measured in the energy range of 100–400 MeV/u. To measure cross sections as excitation …

Modeling in vivo relative biological effectiveness in particle therapy for clinically relevant endpoints

A Lühr, C von Neubeck, S Helmbrecht… - Acta …, 2017 - Taylor & Francis
Background: The relative biological effectiveness (RBE) of particle therapy compared to
photon radiotherapy is known to be variable but the exact dependencies are still subject to …

Design and implementation of a robust and cost-effective double-scattering system at a horizontal proton beamline

S Helmbrecht, M Baumann, W Enghardt… - Journal of …, 2016 - iopscience.iop.org
Purpose: particle therapy has the potential to improve radiooncology. With more and more
facilities coming into operation, also the interest for research at proton beams increases …

Monte Carlo simulations of spatial LET distributions in clinical proton beams

L Grzanka, O Ardenfors, N Bassler - Radiation protection …, 2018 - academic.oup.com
The linear energy transfer (LET) is commonly used as a parameter which describes the
quality of the radiation applied in radiation therapy with fast ions. In particular in proton …