Mast cells are important effector cells of the immune system and recent studies show that
they have immunomodulatory roles in diverse processes in both health and disease. Mast …

Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities
worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has …

Skin is the largest organ of the body with a complex network of multitude of cell types that
perform plastic and dynamic cellular communication to maintain several vital processes …

Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by
causing many of the symptoms associated with allergic reactions. In addition, recent …

Chymases, serine proteases exclusively expressed by mast cells, have been implicated in
various pathological conditions. However, the basis for these activities is not known, ie the in …

Neuroinflammation is a recognized pathogenic mechanism underlying motor neuron
degeneration in amyotrophic lateral sclerosis (ALS), but the inflammatory mechanisms …

Historically, mast cells were known as a key cell type involved in type I hypersensitivity. Until
last two decades, this cell type was recognized to be widely involved in a number of non …

Atopic dermatitis (AD) is a chronic itching (pruritic) skin disease. It results from a complex
interplay between strong genetic and environmental factors. Genome screens of families …

Since we live in a dirty environment, we have developed many host defenses to contend
with microorganisms. The epithelial lining of our skin, gastrointestinal tract and bronchial …

Chymase is the most efficient Ang II (angiotensin II)–forming enzyme in the human body and
has been implicated in a wide variety of human diseases that also implicate its many other …