Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …

Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …

Abstract The PI3K/AKT/mTOR pathway is frequently activated in various human cancers and
has been considered a promising therapeutic target. Many of the positive regulators of the …

Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism,
and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can …

Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients
diagnosed annually. In late-stage colorectal cancer, the most commonly used targeted …

Pancreatic neuroendocrine tumors (PanNETs) are a rare but clinically important form of
pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic …