[HTML][HTML] Thinking outside the brain: gut microbiome influence on innate immunity within neurodegenerative disease

AR Merchak, MKL Bolen, MG Tansey, KB Menees - Neurotherapeutics, 2024 - Elsevier
The complex network of factors that contribute to neurodegeneration have hampered the
discovery of effective preventative measures. While much work has focused on brain-first …

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer's disease hippocampus

C Muñoz-Castro, M Mejias-Ortega… - Acta neuropathologica …, 2023 - Springer
Microglia are brain-resident myeloid cells and play a major role in the innate immune
responses of the CNS and the pathogenesis of Alzheimer's disease (AD). However, the …

Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases

M Wang, A Dehlinger, CF Zapata, M Golan… - Nature …, 2023 - nature.com
Disease-modifying therapies (DMTs) are widely used in neuroimmunological diseases such
as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Although …

Single-cell peripheral immunoprofiling of lewy body and Parkinson's disease in a multi-site cohort

T Phongpreecha, K Mathi, B Cholerton, EJ Fox… - Molecular …, 2024 - Springer
Background Multiple lines of evidence support peripheral organs in the initiation or
progression of Lewy body disease (LBD), a spectrum of neurodegenerative diagnoses that …

Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer's-like clinical phenotype

L Lorenzini, L Zanella, M Sannia… - Alzheimer's Research & …, 2024 - Springer
Systemic inflammation and neuroinflammation affect the natural course of the sporadic form
of Alzheimer's disease (AD), as supported by epidemiological and preclinical data, and …

Immunomodulatory Effects of New Phenanthrene Derivatives from Dendrobium crumenatum

V Kongkatitham, A Dehlinger, M Wang… - Journal of Natural …, 2023 - ACS Publications
Three new phenanthrene derivatives (1, 2, 4), one new fluorenone (3), and four known
compounds (5–8) were isolated from the ethyl acetate extract of Dendrobium crumenatum …

A year in review: brain barriers and brain fluids research in 2022

RF Keep, HC Jones, MG Hamilton… - Fluids and Barriers of the …, 2023 - Springer
This aim of this editorial is to highlight progress made in brain barrier and brain fluid
research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers …

1,2-13C2-Glucose Tracing Approach to Assess Metabolic Alterations of Human Monocytes under Neuroinflammatory Conditions

G Giacomello, C Otto, J Priller, K Ruprecht… - Current issues in …, 2023 - mdpi.com
Neuroinflammation is one of the common features in most neurological diseases including
multiple sclerosis (MScl) and neurodegenerative diseases such as Alzheimer's disease …

Cognitive concerns are a risk factor for mortality in people with HIV and coronavirus disease 2019

DR Wilcox, EA Rudmann, E Ye, A Noori, C Magdamo… - Aids, 2023 - journals.lww.com
Background: Data supporting dementia as a risk factor for coronavirus disease 2019 (COVID-
19) mortality relied on ICD-10 codes, yet nearly 40% of individuals with probable dementia …

Neurotransmission of Immune Cells

M Consentino, S Valdebenito, E Eugenin - Neuroimmune Pharmacology …, 2024 - Springer
For decades, the interactions between the peripheral immune system and the brain have
played a key role in disease. However, the molecular, biochemical, and cellular interactions …