Recent advances in immunotherapy have affirmed the curative potential of T cell-based
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …

Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …

Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in
multiple biological processes. However, the regulatory mechanism and functional …

Over the past decades, our understanding of microbial metabolism has increased
dramatically. Metabolomics, a family of techniques that are used to measure the quantities of …

Long-chain acyl-CoAs (LC-acyl-CoAs) are important intermediary metabolites and are also
thought to function as intracellular signaling molecules; however, the direct effects of LC-acyl …

Cells in multicellular organisms experience diverse neighbors, signals, and evolving
physical environments that drive functional and metabolic demands. To maintain proper …

Metabolism encompasses a series of intricate biochemical processes that are vital for the
sustenance of life in organisms. Metabolomics, an essential scientific discipline, is a field of …

Metabolism is crucial for development through supporting cell growth, energy production,
establishing cell identity, developmental signaling and pattern formation. In many model …

The astrocyte-neuron lactate shuttle (ANLS) model posits that astrocyte-generated lactate is
transported to neurons to fuel memory processes. However, neurons express high levels of …

With the emergence of next‐generation nucleotide sequencing and mass spectrometry‐
based proteomics and metabolomics tools, we have comprehensive and scalable methods …