Lung endothelium, tau, and amyloids in health and disease
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
[HTML][HTML] Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics
Many people living with dementia and cognitive impairment have dysfunctional
mitochondrial and insulin-glucose metabolism resembling type 2 diabetes mellitus and old …
mitochondrial and insulin-glucose metabolism resembling type 2 diabetes mellitus and old …
Effects of the clock modulator nobiletin on circadian rhythms and pathophysiology in female mice of an Alzheimer's disease model
E Kim, K Nohara, M Wirianto, G Escobedo Jr, JY Lim… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is an age-related neurodegenerative disorder and the most
common cause of dementia. Various pathogenic mechanisms have been proposed to …
common cause of dementia. Various pathogenic mechanisms have been proposed to …
[HTML][HTML] The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer's disease model
M Wirianto, CY Wang, E Kim, N Koike… - The FASEB …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a devastating neurodegenerative disorder, and there is a
pressing need to identify disease‐modifying factors and devise interventional strategies. The …
pressing need to identify disease‐modifying factors and devise interventional strategies. The …
[HTML][HTML] Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer's pathology: Insights and therapeutic approaches from periphery
Alzheimer's disease (AD) is an age-associated, multifactorial neurodegenerative disorder
that is incurable. Despite recent success in treatments that partially improve symptomatic …
that is incurable. Despite recent success in treatments that partially improve symptomatic …
Advances in Molecular Psychiatry – March 2023: mitochondrial function, stress, neuroinflammation – bipolar disorder, psychosis, and Alzheimer's disease
In this issue of Molecular Psychiatry, we have multiple articles that present exciting
advances. Mitochondrial dysfunction is a topic that we are highlighting, and it is addressed …
advances. Mitochondrial dysfunction is a topic that we are highlighting, and it is addressed …
[HTML][HTML] Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases
R Ullah, EJ Lee - Experimental Neurobiology, 2023 - ncbi.nlm.nih.gov
This review examines the role of impaired amyloid-β clearance in the accumulation of
amyloid-β in the brain and the periphery, which is closely associated with Alzheimer's …
amyloid-β in the brain and the periphery, which is closely associated with Alzheimer's …
Isotope‐labeled amyloid‐β does not transmit to the brain in a prion‐like manner after peripheral administration
M Brackhan, G Calza, K Lundgren, P Bascunana… - EMBO …, 2022 - embopress.org
Findings of early cerebral amyloid‐β deposition in mice after peripheral injection of amyloid‐
β‐containing brain extracts, and in humans following cadaveric human growth hormone …
β‐containing brain extracts, and in humans following cadaveric human growth hormone …
[HTML][HTML] Aged cattle brain displays Alzheimer's disease-like pathology and promotes brain amyloidosis in a transgenic animal model
I Moreno-Gonzalez, G Edwards III, R Morales… - Frontiers in aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Although the
cause of AD neurodegenerative changes is not fully understood, extensive evidence …
cause of AD neurodegenerative changes is not fully understood, extensive evidence …
Transmission of cerebral β-amyloidosis among individuals
T Hamaguchi, K Ono, M Yamada - Neurochemical Research, 2022 - Springer
Deposition of amyloid β protein (Aβ) in the brain (cerebral β-amyloidosis) is a hallmark of
Alzheimer's disease (AD). So far, there have been increasing number of experimental …
Alzheimer's disease (AD). So far, there have been increasing number of experimental …