BACKGROUND Proglucagon can be processed to glucagon-like peptide1 (GLP-1) within
the islet, but its contribution to islet function in humans remains unknown. We sought to …

Sodium-glucose cotransporter-2 (SGLT2) inhibition and lactation result in the excretion of
large amounts of glucose in urine or milk and are associated with a lower risk of …

The discovery of long-acting incretin receptor agonists represents a major stride forward in
tackling the dual epidemic of obesity and diabetes. Here we outline the evolution of incretin …

Glucagon is generally defined as a counterregulatory hormone with a primary role to raise
blood glucose concentrations by increasing endogenous glucose production (EGP) in …

Soon after publication of the radioimmunoassay to measure circulating insulin in 1960,
several critical observations were made that added new depth to the understanding of …

Evaluation of insulin secretory capacity is essential to understand the pathophysiologic
condition of individuals with diabetes and assess the efficacy of drugs used in the treatment …

Protein ingestion concurrently stimulates euglycemic glucagon and insulin secretion, a
response that is particularly robust with rapidly absorbing proteins. Previously, we have …

Orchestrated hormonal interacts in response to feeding and fasting play a pivotal role in
regulating glucose homeostasis. Here, we show that in obesity, the production of follistatin …