A substantial amount of research has shown that N-methyl-D-aspartate receptors (NMDARs)
may play a key role in the pathophysiology of several neurological diseases, including …

Behavioral scoring is commonly used to access seizure intensity in different seizure models.
Racine's scale, originally developed for the amygdala-kindling model, is also frequently …

Epilepsy accounts for a significant portion of the disease burden worldwide and high
mortality especially for those that epilepsy does not remit. With the current explosion in …

Epilepsy is a major disorder affecting millions of people. Although modern
electrophysiological and imaging approaches provide high-resolution access to the multi …

A quantitative description of motor seizures induced by pentylenetetrazol (PTZ, metrazol)
was performed. Seizures were induced by PTZ in doses from 40 to 120 mg/kg sc in 477 …

We examined the potentiation by ketamine of the γ-aminobutyric acid A (GABA A) receptor
function using convulsive and anesthetic behavioral models in adult male ddY mice …

Four guanidino compounds that are known to accumulate in uremia, namely creatinine,
guanidine, guanidinosuccinic acid and methylguanidine, were administered …

CDKL5 deficiency disorder (CDD) is an infantile, epileptic encephalopathy presenting with
early-onset seizures, intellectual disability, motor impairment, and autistic features. The …

Status epilepticus (SE), a neurological emergency both in adults and in children, could lead
to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most …

Objective: The aim of the study to elicit effects of pure quercetin in pentylenetetrazole (PTZ)
and picrotoxin induced seizures. Materials and methods: Each animal group was divided …