Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the
immobilization and digestion of prey. The most common snake venom enzymes include …

Snake venom contains mixture of bioactive proteins and polypeptides. Most of these
proteins and polypeptides exist as monomers, but some of them form complexes in the …

Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom,
was the first snake venom protein to be purified and crystallized. Crotoxin is a heterodimeric …

Ophidian envenomation is an important health problem in Brazil and other South American
countries. In folk medicine, especially in developing countries, several vegetal species are …

The crystal structure of crotoxin, a potent presynaptic neurotoxin from Crotalus
durissusterrificus, was solved at 1.35 Å resolution. It shows the architecture of the three …

Animal venoms comprise a complex mixture of components that affect several biological
systems. Based on the high selectivity for their molecular targets, these components are also …

The Flaviviridae family includes several virus pathogens associated with human diseases
worldwide. Within this family, Dengue virus is the most serious threat to public health …

Crotoxin (CTX), a heterodimeric phospholipase present in venom of snakes of the genus
Crotalus, has demonstrated a broad spectrum of pharmacological properties, such as …

Abstract Estrogen receptor-positive (ER+) breast cancer is the most diagnosed subtype of
breast cancer. Currently, aromatase inhibitors (AIs) are used as first-line treatment option in …

Phospholipases A2 (PLA2s) are membrane-associated enzymes that hydrolyze
phospholipids at the sn-2 position, releasing lysophospholipids and free fatty acids …